GLP-1

Satya Bio Report | Updated February 2, 2026

Curated Database - Investment-grade data, manually verified (Last updated: 2026-01-29)
$7.8B
Committed Capital
7
Phase 3 Assets
1
BTD Designations
39
Active Trials
25
Curated Assets

Investment Metrics

$7.8B
Committed
(upfront + equity)
$22.8B
Total Potential
(w/ milestones)
7
Phase 3 Assets
1
BTD Designations
10
Deals Tracked
Largest Deal: MET-097i — $4.9B committed to Metsera (acquired) ($4.9B potential with milestones)

Trials by Phase

Phase 2
30
Not Applicable
93
Phase 4
37
Phase 3
25
Phase 1
37
Phase 1/2
6
Phase 2/3
5

Top Sponsors

SponsorTrialsType
Novo Nordisk A/S 9 Industry
Eli Lilly and Company 8 Industry
University of Copenhagen 7 Academic
University Hospital, Gentofte, Copenhagen 4 Academic
University Hospital, Basel, Switzerland 4 Academic
University of Pennsylvania 3 Academic
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School 3 Academic
Sanofi 3 Industry
Mayo Clinic 3 Academic
AstraZeneca 3 Industry

Competitive Landscape: GLP-1 Assets (25)

25 assets tracked • 10 deals worth $7.8B • 7 in Phase 3

By Modality

Other20 ($7.8B)
Small Molecule5

By Phase

Approved6
Phase 37
Phase 29
Phase 13

By Owner Type

Big Pharma16
Chinese Biotech5
Biotech4

Regulatory Designations

BTD1
ODD0
PRIME0
Fast Track3
Semaglutide (Ozempic/Wegovy/Rybelsus)
NN9535, Ozempic, Wegovy, Rybelsus
Approved Active
Other Peptide GLP-1 Agonist
Novo Nordisk (Big Pharma)
Lead: T2D, Obesity, CV Risk
~15-17% weight loss (Wegovy); FLOW: 24% kidney risk reduction
Tirzepatide (Mounjaro/Zepbound)
LY3298176, Mounjaro, Zepbound
Approved Active
Other Dual Peptide GLP-1/GIP Agonist
Eli Lilly (Big Pharma)
Lead: T2D, Obesity
~21-22.5% weight loss; SUMMIT: 33% CV death/HF reduction
Liraglutide (Victoza/Saxenda)
NN2211, Victoza, Saxenda
Approved Active
Other Peptide GLP-1 Agonist
Novo Nordisk (Big Pharma)
Lead: T2D, Obesity
~8% weight loss
Dulaglutide (Trulicity)
LY2189265, Trulicity
Approved Active
Other Peptide GLP-1 Agonist
Eli Lilly (Big Pharma)
Lead: T2D
REWIND: 12% CV risk reduction
Exenatide (Byetta/Bydureon)
AC2993, Byetta, Bydureon
Approved Active
Other Peptide GLP-1 Agonist
AstraZeneca (Big Pharma)
Lead: T2D
Modest efficacy
Mazdutide
IBI362, LY3305677
Approved Active
Other Dual Peptide GCG/GLP-1 Agonist
Innovent Biologics (Chinese Biotech) + Eli Lilly (ex-China)
Lead: Obesity, T2D
GLORY-1: 14.8% (6mg), GLORY-2: 20.1% (9mg)
Orforglipron
LY3502970
Phase 3 Active
Small Molecule Small Molecule GLP-1 Agonist
Eli Lilly (Big Pharma)
Lead: Obesity, T2D
Phase 2: 14.7% weight loss at 36 weeks
CagriSema
NN9838
Phase 3 Active
Other Peptide Combination (GLP-1 + Amylin)
Novo Nordisk (Big Pharma)
Lead: Obesity
Phase 2: ~15.6% weight loss at 32 weeks
Retatrutide
LY3437943
Phase 3 Active
Other Triple Peptide Agonist (GLP-1/GIP/GCGR)
Eli Lilly (Big Pharma)
Lead: Obesity
Phase 2: ~24% weight loss at 48 weeks
Survodutide
BI 456906
Phase 3 Active
Other Dual Peptide GCGR/GLP-1 Agonist
Boehringer Ingelheim (Big Pharma) + Zealand Pharma
Lead: Obesity, MASH
$0 committed to Zealand Pharma ★ unverified
Phase 2: ~19% weight loss; 83% MASH improvement
VK2735
VK2735
Phase 3 Active
Other Dual Peptide GLP-1/GIP Agonist
Viking Therapeutics (Biotech)
Lead: Obesity
Phase 2: 14.7% at 13 weeks (highest dose)
MariTide
AMG 133
Phase 3 Active
Other Bispecific Antibody-Peptide (GLP-1R agonist + GIPR antagonist)
Amgen (Big Pharma)
Lead: Obesity
Phase 2: ~20% weight loss with monthly dosing
HRS9531
HRS9531
Phase 3 Active
Other Dual Peptide GLP-1/GIP Agonist
Hengrui Pharma (Chinese Biotech) + Kailera (US)
Lead: Obesity
$0 committed to Kailera ★ unverified
Phase 3: ~18% weight loss at 48 weeks
Pemvidutide
ALT-801
Phase 2 Active
Other Dual Peptide GLP-1/GCGR Agonist
Altimmune (Biotech)
Lead: MASH, Obesity
Phase 2: 80% liver fat reduction
Petrelintide
ZP8396
Phase 2 Active
Other Long-Acting Amylin Analog
Zealand Pharma (Biotech) + Roche
Lead: Obesity
$1.6B committed to Roche
• $1.6B upfront
• Up to $3.6B in milestones
• Total potential: $5.3B
Phase 1b: 8.6% at 16 weeks
Aleniglipron
GSBR-1290
Phase 2 Active
Small Molecule Small Molecule GLP-1 Agonist
Structure Therapeutics (Biotech)
Lead: Obesity, T2D
Phase 2a: 6.2% weight loss at 12 weeks
Elecoglipron
AZD5004
Phase 2 Active
Small Molecule Small Molecule GLP-1 Agonist
AstraZeneca (Big Pharma) + Eccogene
Lead: Obesity, T2D
$0 committed to Eccogene (Shanghai) ★ unverified
Phase 1: 5.8% at 4 weeks
CT-388
CT-388
Phase 2 Active
Other Dual Peptide GLP-1/GIP Agonist
Roche (Big Pharma)
Lead: Obesity, T2D
Data pending
Efinopegdutide
MK-6024, HM12525A
Phase 2 Active
Other Dual Peptide GLP-1/GCGR Agonist
Merck (Big Pharma) + Hanmi
Lead: MASH
$0 committed to Hanmi Pharmaceutical ★ unverified
72.7% liver fat reduction vs 42.3% semaglutide
Amycretin
NNC0487-0111
Phase 2 Active
Other Dual Peptide GLP-1/Amylin Agonist
Novo Nordisk (Big Pharma)
Lead: Obesity
Phase 1: ~13% at 12 weeks (oral)
BI 3034701
BI 3034701
Phase 2 Active
Other Triple Agonist (GLP-1/GIP/GCGR)
Boehringer Ingelheim (Big Pharma) + Gubra
Lead: Obesity
$0 committed to Gubra ★ unverified
Phase 1 safety/efficacy positive
Noiiglutide
HRS-7535
Phase 2 Active
Small Molecule Small Molecule GLP-1 Agonist
Hengrui (Chinese Biotech) + Kailera (US)
Lead: T2D, Obesity
$0 committed to Kailera ★ unverified
Phase 2: competitive weight loss data
MET-097i
MET-097i
Phase 1 Active
Other GLP-1 Agonist (Long-acting)
Pfizer (Big Pharma)
Lead: Obesity
$4.9B committed to Metsera (acquired)
• $4.9B upfront
• Total potential: $4.9B
Data pending
SYH2082
SYH2082
Phase 1 Active
Other Dual GLP-1/GIP Agonist (Monthly)
CSPC Pharmaceuticals (Chinese Biotech) + AstraZeneca
Lead: Obesity, T2D
$1.2B committed to AstraZeneca
• $1.2B upfront
• Up to $3.5B in milestones
• Total potential: $4.7B
Preclinical data positive
YP05002
YP05002
Phase 1 Active
Small Molecule Small Molecule GLP-1 Agonist
YaoPharma (Chinese Biotech) + Pfizer
Lead: Obesity
$0 committed to Pfizer ★ unverified
Data pending

BTD Breakthrough Therapy   ODD Orphan Drug   PRIME EU Priority   FT Fast Track

Clinical Trials (233)

NCT IDTitlePhaseStatusSponsorEnrollmentStart
NCT06518837 Tirzepatide for Weight Loss Intervention in Early-Stage Hormone Receptor Positive/HER2 Negative Breast Cancer Phase 2 Recruiting Rutgers, The State University of New Jersey 40 2024-10-30
NCT03713502 Enteropathy and Diabetes in HIV Patients Not Applicable Unknown National Institute for Medical Research, Tanzania 1947 2019-05-01
NCT02097342 Effect of Linagliptin on Insulin Sensitivity and Pancreatic Beta Cell Function in Patients With Type 2 Diabetes Mellitus Phase 4 Unknown Post Graduate Institute of Medical Education and Research, Chandigarh 30 2013-12
NCT03439072 G-Pen™ Compared to Lilly Glucagon for Hypoglycemia Rescue in Adults With Type 1 Diabetes Phase 3 Completed Xeris Pharmaceuticals 81 2018-01-23
NCT01755572 Blood Pressure Outcomes With Liraglutide Therapy Phase 4 Completed Mount Sinai Hospital, Canada 22 2013-01
NCT01572753 Investigation of Optimal Dosing Conditions for a Long Acting GLP-1 Analogue in Healthy Male Subjects Phase 1 Completed Novo Nordisk A/S 161 2012-04-12
NCT04192019 Micro Glucagon During Exercise in Type 1 Diabetes Phase 1 Withdrawn Insel Gruppe AG, University Hospital Bern - 2023-04
NCT01449019 The Role of Endogenous Glucagon-like Peptide 1 (GLP-1) in Type 2 Diabetes Mellitus (T2DM) Phase 1 Completed Ludwig-Maximilians - University of Munich 24 2006-12
NCT07254572 Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes Phase 4 Recruiting National Institute of Cardiology, Warsaw, Poland 300 2025-07-10
NCT06017544 GLP-1RAs) and SGLT2is Combination Therapy and MACEs in Patients with Type 2 Diabetes. Not Applicable Completed University of Campania Luigi Vanvitelli 257 2017-01-01
NCT01161862 Integration of Continuous Glucose Monitoring Into a BiHormonal Closed-Loop Artificial Pancreas Not Applicable Completed Boston University Charles River Campus 24 2010-07
NCT01851694 Beta-cell Response to Incretin Hormones in Cystic Fibrosis Not Applicable Recruiting University of Pennsylvania 45 2013-05
NCT04537923 A Study of Tirzepatide (LY3298176) Versus Insulin Lispro (U100) in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine (U100) With or Without Metformin Phase 3 Completed Eli Lilly and Company 1428 2020-10-19
NCT01232946 Cooperation of Insulin and GLP-1 on Myocardial Glucose Uptake Not Applicable Completed Indiana University 30 2012-01
NCT01043445 -Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans. Not Applicable Completed Glostrup University Hospital, Copenhagen 8 2009-09
NCT06737042 Efficacy and Safety of GZR18 Every 2 Weeks Versus Tirzepatide and Placebo in Obese or Overweight Participants Phase 2 Not yet recruiting Gan and Lee Pharmaceuticals, USA 285 2025-02-12
NCT01524705 FLuctuATion Reduction With inSULin and Glp-1 Added togetheR (FLAT-SUGAR) Phase 4 Completed University of Washington 102 2012-08
NCT04133922 Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes Phase 1 Withdrawn University of Virginia - 2019-10-14
NCT01847313 The Effect of Glucagon-like-peptide 1 (GLP-1) Receptor Agonism on Diabetic Kidney Disease Phase 3 Completed Karl Neff 20 2013-04
NCT02650596 Effects of GLP-1 on Chronic Heart Failure Not Applicable Unknown Shi Yang 68 2016-01
NCT07055386 A Study to Compare the Efficacy and Safety of GZR102 Injection and GZR18 Injection in Type 2 Diabetes Mellitus Phase 2 Recruiting Gan & Lee Pharmaceuticals. 90 2025-08-07
NCT06373146 A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity Phase 2 Recruiting Eli Lilly and Company 392 2024-04-24
NCT02128022 Cardioprotective Effects of GLP-1 and Their Mechanisms Phase 1 Completed Papworth Hospital NHS Foundation Trust 32 2014-07
NCT01374594 Importance of Meal Fat Content and Gall Bladder Emptying for Postprandial GLP-1 Secretion in Type 2 Diabetes Patients Not Applicable Completed University Hospital, Gentofte, Copenhagen 30 2011-06
NCT05196958 Interest of GLP1 Analogues in Overweight Type 2 Diabetic Patients With Chronic Inflammatory Bowel Disease Not Applicable Unknown Fondation Hôpital Saint-Joseph 20 2022-01-25
NCT02937558 CSI-Glucagon for Prevention of Hypoglycemia in Children With Congenital Hyperinsulinism Phase 2 Completed Xeris Pharmaceuticals 5 2016-10
NCT07251803 GLP1 Fasting Status and Gastric Retention Using Gastric Ultrasound Not Applicable Not yet recruiting Medical University of South Carolina 150 2026-02-10
NCT02344186 Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes Phase 4 Unknown Temple University 12 2014-05
NCT03341013 A Pilot Study Investigating Bioequivalence Between a Single Dose of Formulation 2 and Formulation 3 of MEDI0382 Phase 1 Completed MedImmune LLC 24 2017-11-30
NCT07083154 GLP-1/GCG Dual Agonist in Type 2 Diabetes With Early Dementia (LIGHT-COG Study) Phase 3 Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School 420 2025-09-27
NCT07130396 Impact of Multivitamin (PhytoMulti®) and a Probiotic (UltraFlora® Balance Probiotic) on Gut Health of People Taking GLP-1 Medication Not Applicable Not yet recruiting Metagenics, Inc. 100 2025-11-01
NCT05500586 The Effects of Glucagon on Hepatic Metabolism Phase 1/2 Recruiting Adrian Vella 21 2022-10-20
NCT02274740 Effect of Lixisenatide on Postprandial Lipid Profile in Obese Type 2 Diabetic Patients Phase 2 Terminated Sanofi 2 2015-04
NCT02333591 Effect of Intact GLP-1 (7-36) and GLP-1 Metabolite (9-36) on Coronary and Peripheral Vascular Function in Adults Phase 4 Completed Mette Zander 25 2016-07
NCT01200940 Metabolic Effects of Non-Nutritive Sweeteners Phase 1/2 Completed National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 118 2010-11-04
NCT00418288 The Effect of GLP-1 on Glucose Uptake in the Brain and Heart in Healthy Men During Hypoglycemia Not Applicable Completed University of Aarhus 10 2007-01
NCT05264727 Glucagon Suppression by Hyperglycemia in the Presence and Absence of Amino Acid Infusion Phase 4 Recruiting Mayo Clinic 60 2023-05-30
NCT05306613 Breaking Sitting and Metabolic Health in Sedentary Lean Adults Not Applicable Completed National Taiwan Normal University 13 2020-12-30
NCT02637388 Effects of Beta-glucan on Energy Intake and Satiety Not Applicable Unknown Queen Margaret University 36 2016-03
NCT07163650 Evaluating Anti-Obesity Medications 6 Months After Metabolic Surgery Phase 4 Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School 60 2025-09-16
NCT05663164 Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS) Not Applicable Completed Universitas Sumatera Utara 30 2022-10-01
NCT02832999 Short Term Effect of Liraglutide Versus Vildagliptine on Insulin Secretion and Insulin Sensitivity in Type 2 Diabetes Phase 4 Completed Yaounde Central Hospital 14 2016-01
NCT02749032 Feed-Back Suppression of Meal-Induced Glucagon-like Peptide 1 (GLP-1) Secretion Phase 1 Completed Michael A. Nauck 24 2011-11
NCT06894784 A Clinical Trial to Evaluate The Effects of Semaglutide and Empagliflozin Combined to Automated Insulin Delivery on Diabetes Control in Adults Living With Type 1 Diabetes Phase 3 Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre 36 2025-04
NCT07350512 Investigating the Acute Effects of Increasing Alanine Exposure in Healthy Participants Not Applicable Not yet recruiting Nicolai Jacob Wewer Albrechtsen 15 2026-01-20
NCT05822167 Effect of Food Temperature and Diet Composition on Satiety, Satiety Hormones, Chewing Time and Neuronal Activity Not Applicable Completed Khyber Medical University Peshawar 13 2023-04-20
NCT02735031 Exenatide and Impaired Hypoglycaemic Awareness in Type 1 Diabetes Phase 2/3 Completed Radboud University Medical Center 10 2017-02-21
NCT07374445 Research on Timing of Liraglutide Therapy in Patients With Obesity After Metabolic Surgery Phase 4 Completed The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School 100 2023-09-01
NCT06038734 Using Point-of-Care-Ultrasound (POCUS) to Assess Gastric Contents Among Fasting Pre-operative Patients Taking GLP-1 Agonists. Not Applicable Completed University of North Carolina, Chapel Hill 108 2023-11-10
NCT03455049 The Effect of Andrographis Paniculata to GLP-1, Fasting Insulin, Insulin 2-h Post OGTT, and HOMA-IR Not Applicable Completed Indonesia University 73 2017-10-17

Showing 50 of 233 trials. Download Excel for complete data.

Publications (50)

PMIDTitleAuthorsJournalYear
39114288 Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists. Liu [object Object] 2024
38843460 Efficacy and Safety of GLP-1 Medicines for Type 2 Diabetes and Obesity. Drucker [object Object] 2024
31002893 GLP-1: Molecular mechanisms and outcomes of a complex signaling system. Smith, Hackett, Galli et al. [object Object] 2019
32396843 How May GIP Enhance the Therapeutic Efficacy of GLP-1? Samms, Coghlan, Sloop [object Object] 2020
27030669 GLP-1 and weight loss: unraveling the diverse neural circuitry. Kanoski, Hayes, Skibicka [object Object] 2016
22945360 GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus. Meier [object Object] 2012
37454782 GLP-1 receptor agonists and diabetic retinopathy: A meta-analysis of randomized clinical trials. Kapoor, Sarvepalli, D'Alessio et al. [object Object] 2023
32077010 Effects of GLP-1 and Its Analogs on Gastric Physiology in Diabetes Mellitus and Obesity. Maselli, Camilleri [object Object] 2021
34981502 Boosting GLP-1 by Natural Products. Yaribeygi, Jamialahmadi, Moallem et al. [object Object] 2021
36639119 Dual GIP/GLP-1 receptor agonists: New advances for treating type-2 diabetes. Scheen [object Object] 2023
33880754 The therapeutic potential of GLP-1 receptor biased agonism. Jones [object Object] 2022
39715341 GLP-1 and Its Analogs: Does Sex Matter? Börchers, Skibicka [object Object] 2025
34519026 Glucagon-like peptide-1 (GLP-1) signalling in the brain: From neural circuits and metabolism to therapeutics. Kabahizi, Wallace, Lieu et al. [object Object] 2022
36569936 GLP-1 receptor agonist as a modulator of innate immunity. Chen, Mei, Wei et al. [object Object] 2022
26308095 Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide. Lau, Bloch, Schäffer et al. [object Object] 2015
29617641 Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. Drucker [object Object] 2018
39980336 GLP-1 Receptor Agonists: Promising Therapeutic Targets for Alcohol Use Disorder. Jerlhag [object Object] 2025
40466247 GLP-1-based medications: Mechanisms involved in obesity treatment. Salvador [object Object] 2025
38532322 GLP-1/GLP-1RAs: New Options for the Drug Treatment of NAFLD. Jiang, Zang [object Object] 2024
33935978 Emerging Role of Caveolin-1 in GLP-1 Action. Puddu, Maggi [object Object] 2021

Top Authors (20)

Authors ranked by publication count from PubMed search results

NameInstitutionPublicationsFirst AuthorLast AuthorStatus
David D'Alessio Duke University 3 1 1 Active
Daniel J Drucker University of Toronto 2 2 0 Active
Karolina P Skibicka University of Gothenburg 2 0 2 Active
Elisabet Jerlhag University of Gothenburg 2 2 0 Active
LongQing Zhang University of Science and Technology 2 1 0 Active
Chen-Yang Zhang Capital Medical University 2 0 1 Active
Qiyuan Keith Liu MedStar Montgomery Medical Center 1 1 0 Active
Nicholas K Smith Vanderbilt University 1 1 0 Inactive
Troy A Hackett Vanderbilt University 1 0 0 Inactive
Aurelio Galli University of Alabama at Birmingham 1 0 0 Inactive
Charles R Flynn Vanderbilt University 1 0 1 Inactive
Ricardo J Samms Diabetes and Complications 1 1 0 Inactive
Matthew P Coghlan Diabetes and Complications 1 0 0 Inactive
Kyle W Sloop Diabetes and Complications 1 0 1 Inactive
Scott E Kanoski University of Southern California 1 1 0 Inactive
Matthew R Hayes University of Pennsylvania 1 0 0 Inactive
Juris J Meier Division of Diabetology 1 1 0 Inactive
Ishani Kapoor Drexel University 1 1 0 Active
Swara M Sarvepalli Central Michigan University 1 0 0 Active
Dilraj S Grewal Duke University 1 0 0 Active